The Effects of Hovenia dulcis Thunb. Polysaccharide on Alloxan-induced Diabetic Mice
Polysaccharide isolated from Hovenia dulcis Thunb.(HDP) was tested on mice to evaluate its antidiabetic activity. Diabetic mice were ig given different dosages of HDP(50, 100 and 200 mg·kg-1)once daily for 6 weeks. The results showed that the activities were related to the dose of HDP. The fasting blood glucose level of the diabetic mice was decreased by 47.46％ in 200 mg·kg-1 group compared with that of before giving HDP. Compared with that of diabetic control group, in 200 mg·kg-1 group fasting blood glucose level (decreased by 64.50%), liver and kidney coefficients(decreased by 18.12% and 30.36% respectively), the content of malondialdehyde(MDA) in liver, kidney(decreased by 44.00% and 51.27% respectively), the content of triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C)in serum(decreased by 26.32%, 26.53% and 35.71% respectively) were significantly decreased; Weight(increased by 16.73%), the content of blood insulin, high density lipoprotein cholesterol(HDL-C) and liver glycogen(increased by 33.14%, 57.14% and 51.22% respectively), the activity of hexokinase(HK) and pyruvate kinase(PK) in liver (increased by 57.50% and 25.70% respectively) were significantly increased. In liver and kidney the activity of superoxide dismutase(SOD)(increased by 31.58% and 37.19% respectively), glutathione peroxidase(GPx)(increased by 43.51% and 22.42% respectively) and catalase(CAT)(increased by 51.42% and 36.46% respectively) were also increased. While the blood glucose levels in glucose tolerance test were decreased. HDP has hypoglycemic effect on diabetic mice. This action may be related with improving anti-oxidation ability, inhibiting lipid peroxidation，regulating lipids metabolism, increasing the storage content of liver glycogen and improving insulin secretion.
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