The Effects of Hovenia dulcis Thunb. Polysaccharide on Alloxan-induced Diabetic Mice

  • YIN Ai-wu
  • GAO Peng-fie
  • HUANG Sai-jin
  • DANG Li-min

Abstract

Polysaccharide isolated from Hovenia dulcis Thunb.(HDP) was tested on mice to evaluate its antidiabetic activity. Diabetic mice were ig given different dosages of HDP(50, 100 and 200 mg·kg-1)once daily for 6 weeks. The results showed that the activities were related to the dose of HDP. The fasting blood glucose level of the diabetic mice was decreased by 47.46% in 200 mg·kg-1 group compared with that of before giving HDP. Compared with that of diabetic control group, in 200 mg·kg-1 group fasting blood glucose level (decreased by 64.50%), liver and kidney coefficients(decreased by 18.12% and 30.36% respectively), the content of malondialdehyde(MDA) in liver, kidney(decreased by 44.00% and 51.27% respectively), the content of triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C)in serum(decreased by 26.32%, 26.53% and 35.71% respectively) were significantly decreased; Weight(increased by 16.73%), the content of blood insulin, high density lipoprotein cholesterol(HDL-C) and liver glycogen(increased by 33.14%, 57.14% and 51.22% respectively), the activity of hexokinase(HK) and pyruvate kinase(PK) in liver (increased by 57.50% and 25.70% respectively) were significantly increased. In liver and kidney the activity of superoxide dismutase(SOD)(increased by 31.58% and 37.19% respectively), glutathione peroxidase(GPx)(increased by 43.51% and 22.42% respectively) and catalase(CAT)(increased by 51.42% and 36.46% respectively) were also increased. While the blood glucose levels in glucose tolerance test were decreased. HDP has hypoglycemic effect on diabetic mice. This action may be related with improving anti-oxidation ability, inhibiting lipid peroxidation,regulating lipids metabolism, increasing the storage content of liver glycogen and improving insulin secretion.

Published
2017-10-08
How to Cite
AI-WU, YIN et al. The Effects of Hovenia dulcis Thunb. Polysaccharide on Alloxan-induced Diabetic Mice. Current Science, [S.l.], v. 113, n. Issue 6, oct. 2017. ISSN 0011-3891. Available at: <http://currentscience.org/index.php/CS/article/view/140>. Date accessed: 15 dec. 2017.