Hyperuricemia in patients with chronic plaque psoriasis and psoriatic arthritis
Introduction: The traditional therapeutic approach does not cover the recognition and the treatment of such a common and underestimated symptom as hyperuricemia in psoriasis and psoriatic arthritis (PsA).
Methods: The prevalence of elevated serum uric acid (SUA) levels in patients with plaque psoriasis was compared to the dependence of the severity of the psoriasis (PASI), the coexistence of PsA and obesity. Levels of SUA were measured in 322 psoriatic patients, including 95 patients with PsA and 98 control individuals matched according to age, sex, CRP, BMI and waist circumference. (Bioethical Committee agreement OIL324/17/Bioet)
Results: Among all psoriatic patients, hyperuricemia was present at a level more than twice of what was found in the control group. Within the entire group of patients, SUA was correlated with age (R = 0,35, p <0.05), BMI (R = 0,42, p <0.05) and waist circumference (R = 0,46, p <0.05). Women with severe psoriasis had a significantly higher SUA. There was no relationship between SUA and PASI among male patients. Furthermore, there was no relationship between SUA and the activity of PsA. A correlation between CRP levels and SUA was found in female patients with PsA (R = 0,29, p <0.05).
Conclusions: Hyperuricemia is common in patients with psoriasis and PsA. The results of our study may indicate that high levels of UA in psoriasis and PsA can be a clinical manifestation of these diseases and depend not only on the presence of metabolic syndrome or its components. It can also be one of the independent factors contributing to the development of inflammation in PsA.
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