Yeast extract inhibits osteosarcoma survival by autophagy inhibition and apoptosis induction
Background: Osteosarcoma is the 6th leading cancer in children under 15 years old. Yeast has been reported to have anti-cancer properties and, the effect of crude yeast extract on osteosarcoma has never been investigated.
Results: Yeast extract significantly inhibited osteosarcoma cell survival with a dose-dependent effect. Real time PCR showed increased expression of p38, cytochrome C, caspase 9, and caspase 3. Real time PCR also showed increased mTOR expression and decreased BECN1 and LC3 expression.
Conclusion: Yeast extract inhibits osteosarcoma survival. Yeast extract’s cellular inhibition of osteosarcoma CRL-1661 may be related to apoptosis induced by autophagy inhibition.
Key Words: Osteosarcoma, yeast extract, autophagy, apoptosis
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